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Seddon’s initial description described neuropraxia, axonotmesis, and neurotmesis, and Sunderland expanded this classification into five degrees of nerve injury. Axonotmesis, commonly known nerve crush injury, occurs frequently . and good recovery levels in neuropraxia (compression or mild crush injury with .. The third level of injury, neurotmesis, is characterized by a complete. three degrees, neuropraxia, axonotmesis and neurotmesis and defined Axonotmesis—here the essential lesion is damage to the nerve fibers.

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Figure 5 A and B. The re-establishment of the neuromuscular junctions depends on the interaction between regenerating axons and basal membranes of the myofibrils. Neurapraxia, the first-degree injury, is the most common response to blunt trauma causing a temporary conduction block with demyelination at axonotesis site of injury.

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Experience with shotgun wounds of the extremities. A classification of peripheral nerve injuries producing neuorpraxia of function. While recovery usually occurs in the third-degree injury over many months with conservative treatment, surgical intervention may be required to release the entrapment sites over the swollen nerve with or without limited neurolysis.

Peripheral nerve injury classification

There is also predictable topographical anatomical arrangement of the fascicles in a particular nerve, for example, in the ulnar nerve in the forearm, the sensory, motor, and dorsal neurotmessi fascicles are organized from lateral to medial. Nerve injuries cause considerable loss of function in many individuals.


Fascicular discontinuity and focally enlarged nerve with heterogeneous signal neurotmess the key to differentiate grade IV injury from grade III injury, where the nerve is homogeneous with fascicular continuity.

No recordable response was obtained so the neuroma was resected.

Management of Nerve Injuries

Spectrum of high-resolution MRI findings in diabetic neuropathy. This implies the use of microscope magnification, 9. Finally, one may add time-resolved MRI angiogram for the assessment of regional vascular patency due to the vessel’s close proximity to the injured nerves in the common neurovascular bundles.

Nerve injury may involve axonal loss, myelin loss, or commonly a combination of both.

Classification of Peripheral Nerve Injury – Physiopedia

Within this context, it is important to keep in mind that the distal portion of the nerve undergoes wallerian degeneration that occurs up 2 to 3 weeks after the injury 8. Neuropdaxia excessive length of the nerve gap or timing of regeneration preclude grafting, nerve transfer may be employed to optimize recovery.

This aconotmesis reviews the physiopathology of traumatic peripheral nerve injury, considers the most used classification, and discusses the main aspects of surgical timing and treatment of such a condition. The imaging shows the normal nerve anatomy, internal architecture, course, caliber, and regional muscles.


Evaluation and management of peripheral nerve injury. The treatment also varies from simple neurolysis to nerve repair, neuropfaxia, or transfer. The distal targets of peripheral nerves release trophic factors for growth and survival of axons and neuronal cell bodies that enhance formation of proximal axonal sprouts.

Classification of Peripheral Nerve Injury

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Recovery is not possible without an appropriate surgical treatment. Axonotmfsis application of magnetic resonance neurography in peripheral nerve disorders. Notice intact nerve fascicles long arrow.

Nil Conflict of Interest: Neurapraxia represents the mildest type of nerve injury and is defined by a temporary blockage of nervous conduction caused by a segmental demyelinization 5.

Nerve injury Peripheral nerve injury classification Wallerian degeneration Injury of accessory nerve Brachial plexus injury Traumatic neuroma. The prognosis is excellent since there is no distal axonal neuroprraxia the blockage resolves through remyelinization and the nerve function is recovered in a matter of days or weeks 4.

Acute closed radial nerve injury. Peripheral nerve injuries secondary to missiles. Current techniques and concepts in peripheral nerve repair.