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Learn more about Bridelia uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Bridelia. Asas, Assas, Bridelia cathartica, Bridelia ferruginea , Bridelia grandis, Bridelia micrantha, Bridelia. In present study we explore dose dependent effects of Bridelia ferruginea on hematological parameters. The hematological responses of albino. A review of Bridelia ferruginea, Combretum glutinosum and Mitragina inermis plants used in zootherapeutic remedies in West Africa: historical.

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At the end of incubation period, iNOS protein levels were measured using western blot using specific antibodies for each protein. Stability and hypoglycemic actions of the leaf extract tablets. Male Wistar albino mice average weight 20 g and male albino rats average weight g used in this study were obtained from the Laboratory Animal Center of the College of Medicine, University of Lagos, Lagos, Nigeria. Discussion Acute toxicity LD 50 testing has been widely used, though often criticized as a parameter for assessing toxicity Lorke, ; Klaassen, ; Timbrel, Studies on the anti-inflammatory and related pharmacological properties of the aqueous extract of Bridelia ferruginea stem bark.

Evidence-Based Complementary and Alternative Medicine

To receive news and publication updates for Evidence-Based Complementary and Alternative Medicine, enter your email address in the box below. One of the major reasons that may be responsible for the increased use of medicinal plants is the notion that all herbal products are safe and effective Farnsworth and Soejarto, ; Soejarto, Concordance of toxicity ferruginsa pharmaceuticals in humans and in animals. Morphological abnormalities were classified as headless sperm, banana head, bricelia neck and bent tail.

In this study the influence of B.

Antiulcer activity of an anthocyanidin from Vaccinium myrtillus. Dissolution was achieved by stirring the mixture on a magnetic stirrer hot plate in a conical flask with a sterile glass rod until it completely dissolved. Preparations of the Extracts Aqueous Extraction: Briefly, cells were collected by scraping and washed twice with cold PBS.

The bark is dark grey, rough and even markedly scaly. Antimicrobial activity of Bridelia ferruginea. A 1 in 20 dilution of semen was carried out using sodium bicarbonate-formalin diluting fluid.


West African Plants – A Photo Guide – Bridelia ferruginea Benth.

The epididymis was processed for sperm analysis assays. When increased therapeutic benefit comes at increased cost. Two different routes of administration oral and intraperitoneal were used for the acute toxicity study as it is conventional and purposeful to evaluate the effect of different routes on safety and development of toxicity following drug administration. It is also used as a purgative and vermifuge Cimanga et al. Journal List Interdiscip Toxicol v. Thus, in this study, the non-significant effect on RBC and HGB in the test groups, compared to the control, implies that there was no change in the oxygen-carrying capacity of the blood and amount of oxygen delivered to the tissues following the administration of various doses of the extract to the test animals.

Table 7 shows the effects of aqueous stem bark extract of Bridelia ferruginea on liver enzymes and renal functions. To investigate whether BFE interferes with these mediators, experiments were carried out to determine its effects on their production in LPS-stimulated BV-2 microglia. Saurauia oroquensisa new species of Actinidiaceae from Colombia. Evidence-Based Complementary and Alternative Medicine. Traditional knowledge compared with a literature seach of modern pharmacology and toxicology.

Hence the extract of Bridelia ferruginea must be rarely used and if its use is inevitable, antioxidant regimen must be incorporated. Animals Male Wistar albino mice average weight 20 g and gridelia albino rats average weight g used in this study were obtained from the Laboratory Animal Center of the College of Medicine, University of Lagos, Lagos, Nigeria.

Determination of serum proteins by means of the biuret reaction.

The mice were randomly divided into five groups bridslia five animals per group. The use of these medicinal plants, however, is not devoid of danger to health and exposes users to the risk of toxicity as well as unwanted side effects Sonhi, ; Hilaly et al. COX-1 is expressed constitutively in most cell types, whereas expression of COX-2 is induced by various factors including inflammatory cytokines and is responsible for the maintenance of the inflammatory process. Despite all these uses, extensive toxicological evaluation has not been carried out.


Effects of aqueous extract of garlic Allium sativum on testicular functions in the rat. The conical flasks were cotton-plugged, sealed with aluminum foil and autoclaved at 0 c for 15 minutes. The toxicity of Callilepsis laureolaa South Africa traditional herbal medecine. Journal of Herbal Medicine. Table 2 Acute i. At the end of the stimulation period, cells were washed with phosphate-buffered saline PBS and lysed as described for western blot.

Instances of adulteration, inappropriate formulations or lack of understanding of drugs and plant interactions or their uses leading to adverse reactions, sometimes life-threatening or lethal to patients, have been reported Ernst, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ferrhginea properly cited.

Bridelia ferruginea

Ethnobotanical literature and folklore uses describe ulcer-protective and anti-diarrheal effects of the aqueous stem ferruginfa Akuodor et al.

Bridelia ferruginea is a woody shrub that grows in the Savannah or rain forests of Africa and has traditionally been used to treat diabetes, arthritis and boils. Recently, Akuodor et al. Anti-microbial activity of Bridelia ferruginea leaves extracts. Bridelia ferruginea is commonly used in traditional African medicine TAM for treating various inflammatory conditions.

Despite all these therapeutic uses of Bridelia ferruginea, extensive toxicological evaluation as stipulated by the WHO has not been carried out. A confirmatory study of the up-and-down method for acute oral toxicity testing.

The aqueous extract of the stem-bark of this plant contains quinones, gallic and catechic tannins, alkaloids, sterols, polyterpenes, polyphenols, reducing compounds, flavonoids and saponosides Nene-Bi et al.

This was however not the case in the present study as an increase in platelets was observed in the test groups compared to the control.